Trifluoroacetic acid → HCID 66727110, compound

HRID 1698211Notes

Reaction equation

HRID 1698211 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]2[NH:15][CH:16]=[CH:17][C:10]=12)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>C(Cl)Cl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH:15]1[C:11]2=[N:12][CH:13]=[CH:14][C:9]([CH2:8][NH2:7])=[C:10]2[CH:17]=[CH:16]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 24229258tert-Butyl [(1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]carbamate

Product 1

HCID 66727110HCID 66727110, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-carbamic acid tert-butyl ester (200 mg, 0.809 mmol) in CH2Cl2 (6 mL) was added trifluoroacetic acid (1.58 mL, 20.6 mmol). After 14 hours, the reaction was concentrated in vacuo to afford the title compound which was used in the without purification.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-29a107eed64f44baa01b5bc935a5df0a
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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