Hydrochloric Acid → 1-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

HRID 1698220Notes

Reaction equation

HRID 1698220 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644, compound

Product 1

HCID 212922721-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

Workup

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-46796126241e4eaba574ee372fa87aef
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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