Hydrochloric Acid → HCID 55284556, compound

HRID 1698231Notes

Reaction equation

HRID 1698231 reaction equation
C1(C)C=CC(S([N:10]2[CH:14]=[C:13]([C@@H:15]([NH:18]S(C(C)(C)C)=O)[CH2:16][CH3:17])[CH:12]=[N:11]2)(=O)=O)=CC=1.Cl>CO.O1CCOCC1>[NH:10]1[CH:14]=[C:13]([C@@H:15]([NH2:18])[CH2:16][CH3:17])[CH:12]=[N:11]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58084249HCID 58084249, compound

Product 1

HCID 55284556HCID 55284556, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid {(S)-1-[1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-propyl}-amide (2.00 g, 5.22 mmol) in MeOH was added a 4 M solution of HCl (5.0 mL, 20 mmol) in dioxane. After 12 hours, the solvent was concentrated in vacuo. The residue was made basic with saturated aqueous NaHCO3 and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound.

Workup

  1. concentrationthe solvent was concentrated in vacuo
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b95b44dad3eb4336a3752c16ded0aeaa
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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