Hydrochloric Acid → HCID 66727435, compound

HRID 1698278Notes

Reaction equation

HRID 1698278 reaction equation
[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:14]S(C(C)(C)C)=O)[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:21].O1CCOCC1>CO>[ClH:21].[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH2:14])[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727572HCID 66727572, compound

Product 1

HCID 66727435HCID 66727435, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(6-methanesulfonyl-pyridin-3-yl)-propyl]amide (50.0 g, 157.0 mmol) in methanol (500 mL) was added a 4 N solution of HCl in dioxane (40.0 mL, 160.0 mmol). After 1 hour, the mixture was concentrated to near dryness (about 40 mL) and the resulting mixture was diluted with ether (500 mL) to afford the title compound.

Workup

  1. concentrationthe mixture was concentrated to near dryness (about 40 mL)
  2. additionthe resulting mixture was diluted with ether (500 mL)

Sources & evidence

ORD record
ord-c758241fb2914f36a3fa7bf2b68a7449
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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