HRID1698313

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78705

Cyclobutanecarbonyl chloride

C5H7ClO

结构：COCCCOc1cc(CN(C(=O)[C@H]2C[C@@H](N)CN(C(=O)OCC3c4ccccc4-c4ccccc43)C2)C2CC2)ccc1Cl.Cl

HCID131729669

未命名化合物

PRODUCTS

生成物

结构：COCCCOc1cc(CN(C(=O)C2CNCC(NC(=O)C3CCC3)C2)C2CC2)ccc1Cl

HCID67273100

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The title compound is prepared analogously as described in Example 61 using (3R*,5S*)-3-amino-5-{[4-chloro-3-(3-methoxy-propoxy)-benzyl]-cyclopropyl-carbamoyl}piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, hydrochloride (Example 92A.) and cyclobutanecarbonyl chloride. MS: 478.4 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 4.97 min.

WORKUP

后处理

custom4.97 min.