HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanecarbonyl chloride → 5-(Cyclobutanecarbonyl-amino)-piperidine-3-carboxylic acid [4-chloro-3-(3-methoxy-propoxy)-benzyl]-cyclopropyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| Reactant | (3R*,5S*)-3-amino-5-{[4-chloro-3-(3-methoxy-propoxy)-benzyl]-cyclopropyl-carbamoyl}-piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, hydrochloride | HCID 131729669 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-(Cyclobutanecarbonyl-amino)-piperidine-3-carboxylic acid [4-chloro-3-(3-methoxy-propoxy)-benzyl]-cyclopropyl-amide | HCID 67273100 | — |
Reaction Steps
The title compound is prepared analogously as described in Example 61 using (3R*,5S*)-3-amino-5-{[4-chloro-3-(3-methoxy-propoxy)-benzyl]-cyclopropyl-carbamoyl}piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester, hydrochloride (Example 92A.) and cyclobutanecarbonyl chloride. MS: 478.4 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 4.97 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163773B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6ebe367ebe6d48dcbbc21602ed838719 |
| Source note | uspto-grants-2012_04 |