反应详情

To a solution of 4.70 g (21.9 mmol) of methyl 2-chloro-3-nitrobenzoate in 300 mL of THF was added dropwise 300 mL of 2-ethanolamine (80 mmol) and the mixture was refluxed over night. The reaction was concentrated to dryness, dissolved in ethyl acetate, and washed aqueous sodium hydrogen carbonate and water. The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo to give 5.00 g (20.8 mmol, 95%) of the title compound.

1. temperaturethe mixture was refluxed over night
2. concentrationThe reaction was concentrated to dryness
3. dissolutiondissolved in ethyl acetate
4. washwashed aqueous sodium hydrogen carbonate and water
5. dry with materialThe organics were dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo