反应详情

温度

120 °C

A mixture of 2-chloro-7-(1-ethylpropyl)-4-(2-furyl)-1-methyl-1H-benzimidazole (42 mg, 0.139 mmol), 2-bromo-4-chlorophenol (87 mg, 0.417 mmol) and potassium carbonate (58 mg, 0.417 mmol) was heated at 120° C. for 18 h under an argon atmosphere. The mixture was diluted with water. The aqueous solution was extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel with a 1-20% ethyl acetate/n-hexane gradient mixture to give 45 mg (0.0950 mmol, 68%) of the title compound) as a colorless crystal.

1. extractionThe aqueous solution was extracted with ethyl acetate
2. washThe extract was washed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue was purified by column chromatography on silica gel with a 1-20% ethyl acetate/n-hexane gradient mixture