Hydrazine hydrate (1:1) → 3-Fluoro-2-hydrazinylpyridine
Reaction equation
Cl[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>C(O)C>[F:8][C:7]1[C:2]([NH:10][NH2:11])=[N:3][CH:4]=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
To a solution of 9.59 g of 2-chloro-3-fluoropyridine in 6 ml of ethanol there was added 6 ml of hydrazine monohydrate, and the mixture was stirred at 60° C. for 3 days. The solution was adsorbed onto 50 g of NH silica gel and purified by NH silica gel column chromatography (ethyl acetate-heptane) to give the title compound (403 mg) as a yellow solid.
Workup
- custompurified by NH silica gel column chromatography (ethyl acetate-heptane)
Sources & evidence
- ORD record
- ord-b75bb6c2fbbf4bf9aa08745c4826350e
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163787B2
Reaction notes
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