Pyrrolidine → HCID 9859818, compound

HRID 1698851Notes

Reaction equation

HRID 1698851 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]([C:8]1[C:12](=[O:13])[O:11][N:10]([C:14](Cl)=[O:15])[C:9]=1[CH2:17][CH2:18][CH3:19])[CH3:7]>ClCCl>[CH2:6]([C:8]1[C:12](=[O:13])[O:11][N:10]([C:14]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:15])[C:9]=1[CH2:17][CH2:18][CH3:19])[CH3:7]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 18322310HCID 18322310, compound

Product 1

HCID 9859818HCID 9859818, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

At 0°C., a solution of 0.43 g (6 mmol) of pyrrolidine in 35 ml of dichloromethane are added dropwise to a solution of 0.44 g (2 mmol) of 4-ethyl-3-propyl-2-(chlorocarbonyl)-5(2H)-isoxazolone in 10 ml of dichloromethane, and the mixture is stirred at room temperature overnight. For work-up, the residue were chromatographed over silica gel using petroleum ether:ethyl acetate (4:1). MS (DCI): 253 (M+H).

Workup

  1. customFor work-up, the residue were chromatographed over silica gel

Sources & evidence

ORD record
ord-e2eab0930652498c98f78cbbe7026fd4
Source dataset
uspto-grants-2002_02
Patent number
US06344471B1

Reaction notes

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