Hydrochloric Acid → HCID 86757761, compound

HRID 1698877Notes

Reaction equation

HRID 1698877 reaction equation
C([NH:4][C:5](C(OCC)=O)([CH2:11]/[CH:12]=[CH:13]/[CH2:14][N:15]1C(=O)C2=CC=CC=C2C1=O)[C:6]([O:8]CC)=[O:7])(=O)C.[ClH:31]>>[ClH:31].[ClH:31].[NH2:4][CH:5]([CH2:11]/[CH:12]=[CH:13]/[CH2:14][NH2:15])[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 5375501HCID 5375501, compound

Product 1

HCID 86757761HCID 86757761, compound

Procedure

Ex-7c) A mixture of 25 g ethyl trans-2-acetamido-2-carbethoxy-6-phthalimido-4-hexenoate and 200 mL 37% HCl is heated under reflux for 20 h and then left at 0-2° C. for 20 h. It is then filtered to remove phthalic acid and the filtrate is reduced to dryness in vacuo. 100 mL of absolute ethanol is then added and evaporated under vacuum. Residual solid is taken up in 100 mL absolute ethanol and filtered to give 13 g of trans-2,6-Diamino-4-hexenoic acid dihydrochloride.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 20 h
  3. filtrationIt is then filtered
  4. customto remove phthalic acid
  5. addition100 mL of absolute ethanol is then added
  6. customevaporated under vacuum
  7. filtrationfiltered

Sources & evidence

ORD record
ord-61f141cf0ddc4c1688ab3e613c3be8f6
Source dataset
uspto-grants-2002_02
Patent number
US06344483B1

Reaction notes

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