Potassium Hydroxide → HCID 18322430, compound

HRID 1698880Notes

Reaction equation

HRID 1698880 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[C:5]([NH:23][C:24](=[O:26])[CH3:25])([C:18]([O:20]CC)=[O:19])[CH2:6][C:7]#[C:8][CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH3:2].[OH-].[K+]>C(O)C.O>[C:24]([NH:23][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:27])([CH2:6][C:7]#[C:8][CH2:9][NH:10][C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[C:18]([OH:20])=[O:19])(=[O:26])[CH3:25]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 14561225HCID 14561225, compound

Product 1

HCID 18322430HCID 18322430, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Ex-8e) Following the procedure described in Tetrahedron Lett Vol.21, 4263, (1980) partial saponification of 10.2 g of ethyl-2-acetylamino-6-t-butyloxycarbonylamino-2-ethoxycarbonyl-4-hexynoate is carried out in ethanol with 1.5 equivalent of KOH in water at 20-25° C. for 3 h to give 2-Acetylamino-6-t-butyloxycarbonylamino-2-ethoxycarbonyl-4-hexynoic acid in 90% yield.

Sources & evidence

ORD record
ord-a7453241ad094f17bf8010beca4d65ee
Source dataset
uspto-grants-2002_02
Patent number
US06344483B1

Reaction notes

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