反应详情

To a solution of 2-(N-methylcarbamoyl)-5-tert-butyl-3-nitropyrrole (1.0 g, 0.4 mmol) in EtOAc (50 mL) under an Ar atmosphere was added 10% Pd/C (50 mg). The mixture was evacuated then placed under a static H2 atmosphere (1 atm.) for 24 h. The resulting slurry was filtered through a pad of Celite® with the aid of EtOAc, and the filtrate was concentrated under reduced pressure to afford 2-(N-methylcarbamoyl)-3-amino-5-tert-butylpyrrole (0.61 g, 70%): 1H-NMR (DMSO-d6) δ1.16 (s, 9H), 2.66 (d, J=4.41 Hz, 3H), 4.89 (br s, 2H), 5.27 (d, 2.58 Hz, 1H), 7.14-7.16 (m, 1H), 9.52 (br s, 1H).

1. customThe mixture was evacuated
2. customfor 24 h
3. filtrationThe resulting slurry was filtered through a pad of Celite® with the aid of EtOAc
4. concentrationthe filtrate was concentrated under reduced pressure