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A mixture of 50.0 g (0.258 mol) of methyl 4-aminothiophen-3-carboxylate-hydrochloride, 700 ml of toluene, 26 g (0.257 mol) of triethylamine and 27 ml (0.283 mol) of ethyl chlorocarbonate was refluxed for 5 hours. The insoluble matter was filtered off, the filtrate was evaporated down in vacuo and the residue was crystallised from petroleum ether. 59.0 g (99.8% of theory) of colourless crystals of melting point 52° C. were obtained.

1. temperaturewas refluxed for 5 hours
2. filtrationThe insoluble matter was filtered off
3. customthe filtrate was evaporated down in vacuo
4. customthe residue was crystallised from petroleum ether
5. custom59.0 g (99.8% of theory) of colourless crystals of melting point 52° C. were obtained