Trifluoroacetic acid → HCID 86587637, compound

HRID 1699241Notes

Reaction equation

HRID 1699241 reaction equation
CC(C)(OC([N:7]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:18][C:17]3=[CH:19][S:20][CH:21]=[C:16]3[NH:15][C:14]2=[O:22])[CH2:9][CH2:8]1)=O)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[NH:7]1[CH2:8][CH2:9][CH:10]([N:13]2[CH2:18][C:17]3=[CH:19][S:20][CH:21]=[C:16]3[NH:15][C:14]2=[O:22])[CH2:11][CH2:12]1.[F:24][C:25]([F:30])([F:29])[C:26]([O-:28])=[O:27]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18321456HCID 18321456, compound

Product 1

HCID 86587637HCID 86587637, compound

Procedure

A mixture of 10.0 g (0.0296 mol) of 3,4-dihydro-3-[1-(1,1-dimethylethoxycarbonyl)-4-piperidinyl]-1H-thieno[3,4-d]pyrimidin-2-one and 50 ml of trifluoroacetic acid was stirred at room temperature for 30 minutes. The residue remaining after removal of the excess trifluoroacetic acid was triturated with diethylether and suction filtered. 5.8 g (55.8% of theory) of colourless crystals were obtained, which were used without further purification.

Workup

  1. customafter removal of the excess trifluoroacetic acid
  2. customwas triturated with diethylether and suction
  3. filtrationfiltered
  4. custom5.8 g (55.8% of theory) of colourless crystals were obtained
  5. customwhich were used without further purification

Sources & evidence

ORD record
ord-dcaf17a0c05f4f5ebef330f6f9424e47
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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