1-Benzyl-4-piperidone → Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine

HRID 1699261Notes

Reaction equation

[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:9]1([CH2:15][N:16]2[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:19]2[CH2:18][CH2:17][N:16]([CH2:15][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:21][CH2:20]2)[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 192201-Benzyl-4-piperidone

HCID 2283491-Methylhomopiperazine

Product 1

HCID 18321160Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepineYield 35%

Procedure

Prepared analogously to Example A11a) from hexahydro-1-methyl-1H-1,4-diazepine and 1-(phenylmethyl)-4-piperidinone in a yield of 35% of theory. Colourless viscous oil.

Sources & evidence

ORD record: ord-59c724e2667049b29dee50a83eda4522
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06344449B1

Reaction notes

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