Sodium hydride → HCID 18321570, compound

HRID 1699281Notes

Reaction equation

HRID 1699281 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH:5]([CH2:11][C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2].[CH3:23][C:24]([C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1)([CH3:26])[CH3:25].[H-].[Na+]>>[C:16]1([CH2:15][O:14][C:12](=[O:13])[CH2:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])([C:4]([O:3][CH2:1][CH3:2])=[O:22])[CH2:31][C:30]2[CH:33]=[CH:34][C:27]([C:24]([CH3:26])([CH3:25])[CH3:23])=[CH:28][CH:29]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzeneHCID 18321175HCID 18321175, compound

Product 1

HCID 18321570HCID 18321570, compoundYield 53%

Procedure

Prepared analogously to Example A62 from diethyl[(phenylmethoxycarbonyl)methyl]-malonoate and 4-(1,1-dimethylethyl)benzylbromide in the presence of sodium hydride in a yield of 53% of theory.

Sources & evidence

ORD record
ord-da8a5c600aa64b69b3bc709e58dc8e68
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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