Hydrochloric Acid → HCID 18321468, compound

HRID 1699285Notes

Reaction equation

HRID 1699285 reaction equation
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][N:17](CC3C=CC=CC=3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1)O.[ClH:28]>[Pd].C(OCC)(=O)C.CO>[ClH:28].[ClH:28].[CH3:27][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18321094HCID 18321094, compound

Product 1

HCID 18321468HCID 18321468, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogously to example A20b) from 4-[4-[4-(dimethyl-amino)-1-hydroxybutyl]phenyl]-1-(phenylmethyl)piperazine by catalytic hydrogenation in the presence of palladium/charcoal and hydrochloric acid in a quantitative yield. Colourless, amorphous substance of Rf 0.37 (eluant: ethyl acetate/methanol 50/50/0.5 v/v/v).

Sources & evidence

ORD record
ord-663ff4b9669e47af9d2826270d56c88e
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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