4-Chlorophenyl isothiocyanate → HCID 178512292, compound

HRID 1699368Notes

Reaction equation

HRID 1699368 reaction equation
[C:1]([NH:3][C:4]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])=[N:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)#[N:2].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[S:29])=[CH:23][CH:22]=1.C(N(C(C)C)CC)(C)C>N1C=CC=CC=1>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][NH:12][C:4]([NH:3][C:1]#[N:2])=[N:5][C:6]2[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=2)=[S:29])=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 164804-Chlorophenyl isothiocyanateHCID 81531DiisopropylethylamineHCID 178512289HCID 178512289, compound

Product 1

HCID 178512292HCID 178512292, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-Cyano-N′-(6-hydroxyhexyl)-N″-4-pyridylguanidine (0.5 g), 4-chlorophenyl isothiocyanate (0.4 g) and diisopropylethylamine (0.32 ml) was mixed in a two-necked flask with a three-way-tap and a septum. The air was exchanged with argon through the three-way-tap. Dry pyridine (10 ml) was added through the septum. The reaction mixture was stirred for 5 days at room temperature.

Sources & evidence

ORD record
ord-10c39c0b7a814b27b3bc6149c728cb98
Source dataset
uspto-grants-2002_02
Patent number
US06346541B1

Reaction notes

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