HCID 18319637, compound → HCID 18319549, compound

HRID 1699377Notes

Reaction equation

HRID 1699377 reaction equation
[OH:1][CH2:2][C:3]1[C:13]2[O:12][CH2:11][CH2:10][C:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[C:13]2[O:12][CH2:11][CH2:10][C:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)=[O:1]

Participants

3

Reactant 1

HCID 18319637HCID 18319637, compound

Product 1

HCID 18319549HCID 18319549, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

A mixture of ethyl 2,3-dihydro-9-hydroxymethyl-1-benzoxepin-4-carboxylate (0.45 g) and manganese (IV) oxide (4.5 g) was stirred under reflux for 1 hour and filtered off. The filtrate was evaporated in vacuo to give a solid of ethyl 2,3-dihydro-9-formyl-1-benzoxepin-4-carboxylate (0.43 g).

Workup

  1. temperatureunder reflux for 1 hour
  2. filtrationfiltered off
  3. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-6af95d4826784047ac077d193790cff0
Source dataset
uspto-grants-2002_02
Patent number
US06346527B1

Reaction notes

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