Sodium Methoxide → HCID 18319541, compound

HRID 1699393Notes

Reaction equation

HRID 1699393 reaction equation
[CH3:1][O-:2].[Na+].Cl[CH2:5][C:6]1[C:16]2[O:15][CH2:14][CH2:13][C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1>CO>[CH3:1][O:2][CH2:5][C:6]1[C:16]2[O:15][CH2:14][CH2:13][C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 18319513HCID 18319513, compound

Product 1

HCID 18319541HCID 18319541, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

28% Sodium methoxide in methanol (1.2ml) was added to a solution of methyl 2,3-dihydro-9-chloromethyl-1-benzoxepin-4-carboxylate (0.8 g) in methanol (8 ml) under ice-cooling and the mixture was stirred at the same temperature for 2 hours. The solvent was removed by concentration and to the residue was added a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo to give methyl 2,3-dihydro-9-methoxymethyl-1-benzoxepin-4-carboxylate (0.48 g).

Workup

  1. temperaturecooling
  2. customThe solvent was removed by concentration and to the residue
  3. additionwas added
  4. additiona mixture of ethyl acetate and water
  5. washThe separated organic layer was washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated in vacuo

Sources & evidence

ORD record
ord-2532d975302747379c26515c0254d231
Source dataset
uspto-grants-2002_02
Patent number
US06346527B1

Reaction notes

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