Sodium Methoxide → HCID 18319541, compound

Participants

Reaction Steps

28% Sodium methoxide in methanol (1.2ml) was added to a solution of methyl 2,3-dihydro-9-chloromethyl-1-benzoxepin-4-carboxylate (0.8 g) in methanol (8 ml) under ice-cooling and the mixture was stirred at the same temperature for 2 hours. The solvent was removed by concentration and to the residue was added a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo to give methyl 2,3-dihydro-9-methoxymethyl-1-benzoxepin-4-carboxylate (0.48 g).

Provenance & Evidence