O-Methylhydroxylamine hydrochloride → HCID 73437182, compound

Participants

Reaction Steps

Methyl 2,3-dihydro-9-formyl-1-benzoxepin-4-carboxylate (0.5 g) was added to a mixture of O-methylhydroxylamine hydrochloride (0.25 g) and 28% sodium methoxide in methanol (0.5 ml) in methanol (5 ml) and the mixture was stirred at ambient temperature for 4 hours. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give methyl 2,3-dihydro-9-methoxyiminomethyl-1-benzoxepin-4-carboxylate (0.55 g).

Provenance & Evidence