O-Methylhydroxylamine hydrochloride → HCID 73437182, compound

HRID 1699395Notes

Reaction equation

HRID 1699395 reaction equation
[CH:1]([C:3]1[C:13]2[O:12][CH2:11][CH2:10][C:9]([C:14]([O:16][CH3:17])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)=O.Cl.[CH3:19][O:20][NH2:21].C[O-].[Na+]>CO>[CH3:19][O:20][N:21]=[CH:1][C:3]1[C:13]2[O:12][CH2:11][CH2:10][C:9]([C:14]([O:16][CH3:17])=[O:15])=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 10942334Sodium MethoxideHCID 18319504HCID 18319504, compound

Product 1

HCID 73437182HCID 73437182, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methyl 2,3-dihydro-9-formyl-1-benzoxepin-4-carboxylate (0.5 g) was added to a mixture of O-methylhydroxylamine hydrochloride (0.25 g) and 28% sodium methoxide in methanol (0.5 ml) in methanol (5 ml) and the mixture was stirred at ambient temperature for 4 hours. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to give methyl 2,3-dihydro-9-methoxyiminomethyl-1-benzoxepin-4-carboxylate (0.55 g).

Workup

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-ae10f85783de4721834e21755f875cb0
Source dataset
uspto-grants-2002_02
Patent number
US06346527B1

Reaction notes

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