Hydrochloric Acid → HCID 178478826, compound

Participants

Reaction Steps

To a solution of {2,3-dihydro-9-[2-(tert-butoxycarbonylamino)ethylaminocarbonyl]-1-benzoxepin-4-carbonyl}guanidine (0.8 g) in 1,4-dioxane (8 ml) was added 4N hydrogen chloride in 1,4-dioxane (8 ml) at ambient temperature and the mixture was stirred at the same temperature for 18 hours. Diisopropyl ether (10 ml) was added to the mixture and the precipitate was collected by filtration. The precipitate was recrystallized from a mixture of methanol and diisopropyl ether to give [2,3-dihydro-9-(2-aminoethylaminocarbonyl)-1-benzoxepin-4-carbonyl]guanidine dihydrochloride (0.57 g).

Provenance & Evidence