Hydrochloric Acid → HCID 178478826, compound

HRID 1699405Notes

Reaction equation

HRID 1699405 reaction equation
C(OC([NH:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[C:24]2[O:23][CH2:22][CH2:21][C:20]([C:25]([NH:27][C:28]([NH2:30])=[NH:29])=[O:26])=[CH:19][C:18]=2[CH:17]=[CH:16][CH:15]=1)=[O:13])=O)(C)(C)C.[ClH:31].C(OC(C)C)(C)C>O1CCOCC1>[ClH:31].[ClH:31].[NH2:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[C:24]2[O:23][CH2:22][CH2:21][C:20]([C:25]([NH:27][C:28]([NH2:30])=[NH:29])=[O:26])=[CH:19][C:18]=2[CH:17]=[CH:16][CH:15]=1)=[O:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 178453694HCID 178453694, compound

Product 1

HCID 178478826HCID 178478826, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of {2,3-dihydro-9-[2-(tert-butoxycarbonylamino)ethylaminocarbonyl]-1-benzoxepin-4-carbonyl}guanidine (0.8 g) in 1,4-dioxane (8 ml) was added 4N hydrogen chloride in 1,4-dioxane (8 ml) at ambient temperature and the mixture was stirred at the same temperature for 18 hours. Diisopropyl ether (10 ml) was added to the mixture and the precipitate was collected by filtration. The precipitate was recrystallized from a mixture of methanol and diisopropyl ether to give [2,3-dihydro-9-(2-aminoethylaminocarbonyl)-1-benzoxepin-4-carbonyl]guanidine dihydrochloride (0.57 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customThe precipitate was recrystallized from a mixture of methanol and diisopropyl ether

Sources & evidence

ORD record
ord-8ea5965c8271420583c6265e6eaa11c5
Source dataset
uspto-grants-2002_02
Patent number
US06346527B1

Reaction notes

Loading…