HCID 15548167, compound → HCID 69843821, compound

HRID 1699412Notes

Reaction equation

HRID 1699412 reaction equation
C(OCC)(=O)C.[ClH:7].[OH:8][C@H:9]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:10][N:11]([CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:29])=[CH:23][CH:22]=1)C(=O)OC(C)(C)C>>[ClH:7].[ClH:7].[OH:8][C@H:9]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[CH2:10][NH:11][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 15548167HCID 15548167, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69843821HCID 69843821, compound

Procedure

A 4N hydrogen chloride-ethyl acetate solution (10 ml) was added to 10 ml of an ethanolic solution of 458 mg of tert-butyl (R)-N-(2-hydroxy-2-phenylethyl)-N-[2-[4-[(2-pyridinecarbonyl)amino]phenyl]ethyl]carbamate. The reaction solution was stirred at room temperature for three hours, and the solvent was then evaporated in vacuo. The obtained crude crystals were recrystallized from methanol-ethanol-ethyl acetate to give 289 mg of (R)-4′-[2-[(2-hydroxy-2-phenyl-ethyl)amino]ethyl]-2-pyridinecarboxanilide dihydrochloride.

Workup

  1. customthe solvent was then evaporated in vacuo
  2. customThe obtained crude crystals
  3. customwere recrystallized from methanol-ethanol-ethyl acetate

Sources & evidence

ORD record
ord-f37957724df344f39a54e29bf92f8278
Source dataset
uspto-grants-2002_02
Patent number
US06346532B1

Reaction notes

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