HCID 15548167, compound → HCID 69843821, compound

Participants

Reaction Steps

A 4N hydrogen chloride-ethyl acetate solution (10 ml) was added to 10 ml of an ethanolic solution of 458 mg of tert-butyl (R)-N-(2-hydroxy-2-phenylethyl)-N-[2-[4-[(2-pyridinecarbonyl)amino]phenyl]ethyl]carbamate. The reaction solution was stirred at room temperature for three hours, and the solvent was then evaporated in vacuo. The obtained crude crystals were recrystallized from methanol-ethanol-ethyl acetate to give 289 mg of (R)-4′-[2-[(2-hydroxy-2-phenyl-ethyl)amino]ethyl]-2-pyridinecarboxanilide dihydrochloride.

Provenance & Evidence