反应详情

温度

40 °C

Di-p-toluoyl-L-tartaric acid (1.35 g, 3.50 mmol) was dissolved in ethanol (10 ml) on heating to 40° C. and then synthetic racemic narwedine (1.00 g, 3.50 mmol) was added and the mixture was heated at reflux for 1 h then cooled to 40° C. and stirred for 16 hours at this temperature. The mixture was cooled to ambient temperature, stirred for 2 h and then the white solid was isolated by filtration to give the 1:1 diastereomeric salt [(+)−narwedine] [di-p-toluoyl-L-tartrate] (2.16 g, 92% yield, 96% e.e.).

1. temperaturethe mixture was heated
2. temperatureat reflux for 1 h
3. temperaturethen cooled to 40° C.
4. temperatureThe mixture was cooled to ambient temperature
5. stirringstirred for 2 h
6. customthe white solid was isolated by filtration