関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Narwedine | HCID 10356588 | — |
| 反応物 | Di-para-toluoyl-L-tartaric acid | HCID 29414711 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (+)-Narwedine | HCID 441596 | — |
| 生成物 | di-p-toluoyl-L-tartrate | HCID 29414710 | — |
反応手順
Di-p-toluoyl-L-tartaric acid (1.35 g, 3.50 mmol) was dissolved in ethanol (10 ml) on heating to 40° C. and then synthetic racemic narwedine (1.00 g, 3.50 mmol) was added and the mixture was heated at reflux for 1 h then cooled to 40° C. and stirred for 16 hours at this temperature. The mixture was cooled to ambient temperature, stirred for 2 h and then the white solid was isolated by filtration to give the 1:1 diastereomeric salt [(+)−narwedine] [di-p-toluoyl-L-tartrate] (2.16 g, 92% yield, 96% e.e.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06346618B1 |
|---|
| 出典データセット | uspto-grants-2002_02 |
|---|
| ORD ID | ord-bab2e55dec3849c9bf10f9a01a981ab2 |
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| 出典メモ | uspto-grants-2002_02 |
|---|
