Cesium carbonate → HCID 9859145, compound

HRID 1699441Notes

Reaction equation

[CH3:1][N:2]([CH3:15])[N:3]=[CH:4][CH2:5][CH2:6][C:7]1[C:12](Cl)=[CH:11][CH:10]=[CH:9][C:8]=1[Cl:14].C(=O)([O-])[O-].[Cs+].[Cs+]>>[Cl:14][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[CH2:6][CH:5]=[CH:4][N:3]2[N:2]([CH3:15])[CH3:1]

Participants

Reactant 2

HCID 10796Cesium carbonate

HCID 54348027HCID 54348027, compound

Product 1

HCID 9859145HCID 9859145, compoundYield 35%

Procedure

5-Chloro-1-(dimethylamino)-4H-quinoline was prepared in the same manner as in Example 1 except that 3-(2,6-dichlorophenyl)propionaldehyde N,N-dimethylhydrazone was used in place of 2-chlorophenylacetaldehyde N,N-dimethylhydrazone, cesium carbonate was used in place of t-butoxysodium, and the reaction was conducted at 120° C. for 8 hours. (Yield: 35%).

Sources & evidence

ORD record: ord-4fc34f26134b47269ba476ee7c186808
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06346621B1

Reaction notes

Loading…