2,5-Dimethoxytetrahydrofuran → HCID 15860435, compound

HRID 1699447Notes

Reaction equation

HRID 1699447 reaction equation
[CH3:1][C:2]1([CH3:33])[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:5]=2[S:4](=[O:13])(=[O:12])[N:3]1[CH2:14][CH2:15][CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=[CH:25][CH:24]=2)[CH2:19][CH2:18]1.CO[CH:36]1[CH2:40][CH2:39][CH:38](OC)O1>C(O)(=O)C>[CH3:1][C:2]1([CH3:33])[C:6]2[CH:7]=[CH:8][C:9]([N:11]3[CH:36]=[CH:40][CH:39]=[CH:38]3)=[CH:10][C:5]=2[S:4](=[O:13])(=[O:12])[N:3]1[CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][N:20]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=[CH:25][CH:24]=2)[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 18320646HCID 18320646, compound

Product 1

HCID 15860435HCID 15860435, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The pyrrole ring was assembled by reacting 3,3-dimethyl-2-[3-(4-(1-naphthyl)-1-piperazinyl)prop-1-yl]-6-amino-2,3-dihydro-1,2-benzoisothiazole 1,1-dioxide with 2,5-dimethoxytetrahydrofuran in glacial acetic acid at 100° C. (1 h) in 86% yield.

Workup

  1. customat 100° C.
  2. custom(1 h)

Sources & evidence

ORD record
ord-30d6dad6ab7841168e53446254690aff
Source dataset
uspto-grants-2002_02
Patent number
US06346622B1

Reaction notes

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