Potassium Hydroxide → HCID 54563878, compound

HRID 1699461Notes

Reaction equation

HRID 1699461 reaction equation
C12(C([O:13][C:14]3[CH:15]=[C:16]4[C:21](=[CH:22][CH:23]=3)[O:20][C:19]([C:24]35C[CH:28]6[CH2:29][CH:30]([CH2:32][CH:26]([CH2:27]6)[CH2:25]3)C5)=[CH:18][C:17]4=[O:34])=O)CC3CC(CC(C3)C1)C2.[OH-].[K+]>O1CCOCC1>[OH:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[O:20][C:19]([CH:24]=[CH:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:32]=1)=[CH:18][C:17]2=[O:34]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10895779HCID 10895779, compound

Product 1

HCID 54563878HCID 54563878, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

330 mg 6-(1-adamantoyloxy)-2-(1-adamantyl)-4H-chromen-4-one is dissolved in dioxane and treated with 5 ml of 10% aqueous potassium hydroxide solution. The mixture is stirred for 3 hours at room temperature and then poured into 2M aqueous pH 7 buffer solution. Extraction with ethyl acetate yields after drying and evaporation a crude product which is purified by chromatogaphy. The title compound is obtained [colourless crystals; mp 230°(from 2-propanol)].

Workup

  1. extractionExtraction with ethyl acetate
  2. customyields
  3. customafter drying
  4. customevaporation a crude product which
  5. customis purified by chromatogaphy

Sources & evidence

ORD record
ord-f5948e2dae9f47e9b039a3e1b0ba51d5
Source dataset
uspto-grants-2002_02
Patent number
US06346626B1

Reaction notes

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