Thionyl Chloride → HCID 15450534, compound

HRID 1699487Notes

Reaction equation

HRID 1699487 reaction equation
[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12](O)=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2].S(Cl)([Cl:19])=O>CN(C)C=O.C1(C)C=CC=CC=1>[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12]([Cl:19])=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 15450533HCID 15450533, compound

Product 1

HCID 15450534HCID 15450534, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

5-Acetoxybenzo[b]thiophene-3-carboxylic acid (12) (1,349 mg) prepared above was refluxed for 1.5 hours with dimethylformamide (1 drop), thionyl chloride (1.22 ml) and toluene (25 ml). The solvent was removed under reduced pressure to provide 1,454 mg of the title compound (13).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5786c49965b240c4ab9fa9d983456a1e
Source dataset
uspto-grants-2002_02
Patent number
US06346628B1

Reaction notes

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