反应详情

温度

0 °C

A solution was prepared by adding 50 parts of diethyl ether to 31.1 parts of 2-adamantanone. While keeping the temperature of the solution at or under 10° C., 200 ml of a diethyl ether solution containing ethyl lithium at a concentration of 1.14 mole/liter was added dropwise thereto. The solution was stirred at 0° C. for 2 hours, and then, while keeping the temperature of the solution at or under 10° C., 26.2 parts of methacryloyl chloride (1.2 mole based on 2-methyl-2-adamantanol) was added dropwise. After the completion of addition, the solution was stirred at room temperature for 12 hours. Then precipitated inorganic salts were removed by filtration. The organic layer was washed with 5% aqueous sodium hydrogen carbonate solution and then washed twice with water. The organic layer was concentrated and distilled under reduced pressure to give 2-ethyl-2-adamantyl methacrylate represented by the following formula:

1. customA solution was prepared
2. customunder 10° C.
3. additionwas added dropwise
4. customunder 10° C.
5. additionAfter the completion of addition
6. stirringthe solution was stirred at room temperature for 12 hours
7. customThen precipitated inorganic salts
8. customwere removed by filtration
9. washThe organic layer was washed with 5% aqueous sodium hydrogen carbonate solution
10. washwashed twice with water
11. concentrationThe organic layer was concentrated
12. distillationdistilled under reduced pressure