Hydrochloric Acid → HCID 18369241, compound

HRID 1699728Notes

Reaction equation

HRID 1699728 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[C:14]([F:17])([F:16])[F:15])[N:10]=[C:9]([C:18]([O:20]CC)=[O:19])[C:8](=[O:23])[NH:7]2)([O-:3])=[O:2].[OH-].[K+].O.Cl>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[C:14]([F:17])([F:16])[F:15])[N:10]=[C:9]([C:18]([OH:20])=[O:19])[C:8](=[O:23])[NH:7]2)([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 18369223HCID 18369223, compound

Product 1

HCID 18369241HCID 18369241, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 3,4-dihydro-6-nitro-3-oxo-7-trifluoromethylquinoxaline-2-carboxylate (120 mg, 362 μmol) in ethanol (5 ml) was added 1N aqueous solution of potassium hydroxide (724 μl, 724 μmol), and the mixture was refluxed for 1 hour. After cooling, water was added and the pH value was brought to 2 with concentrated hydrochloric acid. The precipitate was collected by filtration, washed with water and then air-dried to obtain 102 mg of the title compound as colorless powder. Yield 88%.

Workup

  1. temperaturethe mixture was refluxed for 1 hour
  2. temperatureAfter cooling
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-3f0f1e7cc96f4f30bfae99fa621af2f2
Source dataset
uspto-grants-2002_02
Patent number
US06348461B1

Reaction notes

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