Hydrochloric Acid → HCID 18369234, compound

HRID 1699733Notes

Reaction equation

HRID 1699733 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:17])[C:8]([C:12]([O:14]CC)=[O:13])=[N:9]2)=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].[OH-].[K+].O.Cl>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:17])[C:8]([C:12]([OH:14])=[O:13])=[N:9]2)=[CH:4][C:3]=1[C:18]([F:20])([F:19])[F:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 18369171HCID 18369171, compound

Product 1

HCID 18369234HCID 18369234, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 7-bromo-3,4-dihydro-3-oxo-6-trifluoromethylquinoxaline-2-carboxylate (120 mg, 329 μmol) in ethanol (4 ml) were added 1N aqueous solution of potassium hydroxide (1.32 ml, 1.32 mmol) and water (2 ml), and the mixture was refluxed for 30 minutes. After cooling with ice, the pH value was brought to 4 with 1.2N hydrochloric acid. The precipitate was collected by filtration, washed with water and then air-dried to obtain 91.0 mg of the title compound as yellowish brown powder. Yield 82%.

Workup

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureAfter cooling with ice
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-21260b97f02045769311041480917cda
Source dataset
uspto-grants-2002_02
Patent number
US06348461B1

Reaction notes

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