反应详情

To a suspension of (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine hydrochloride (100.0 g, 417 mmol) in tetrahydrofuran (250 mL) at 15° C. was added dropwise a 7.1% aqueous solution of sodium hydroxide (538 mL). Propionyl chloride (44.4 g, 480 mmol) was added dropwise to the reaction mixture. Stirring was continued at room temperature for 30 min. Water (800 mL) was added and crystals precipitated were collected by filtration followed by recrystallization from ethanol:water=1:2 to obtain 99.5 g (yield: 92%) of the title compound.

1. customcrystals precipitated
2. filtrationwere collected by filtration
3. customfollowed by recrystallization from ethanol