2-Fluoroanisole → 3'-Fluoro-2-(3-fluoro-4-methoxyphenyl)-4'-methoxyacetophenone

HRID 1699771Notes

Reaction equation

HRID 1699771 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH3:22]>>[F:14][C:15]1[CH:20]=[C:19]([C:11](=[O:13])[CH2:10][C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=2)[CH:18]=[CH:17][C:16]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 675762-FluoroanisoleHCID 521176(3-Fluoro-4-methoxyphenyl)acetic acid

Product 1

HCID 135263783'-Fluoro-2-(3-fluoro-4-methoxyphenyl)-4'-methoxyacetophenoneYield 77.5%

Procedure

Using 3-fluoro-4-methoxyphenylacetic acid and 2-fluoroanisole as starting materials, the procedures of Preparation Example 7 were repeated likewise, whereby the title compound was obtained in a yield of 77.5%.

Workup

  1. customthe procedures of Preparation Example 7

Sources & evidence

ORD record
ord-8883b50afb3941338f66cdcf644ebcd9
Source dataset
uspto-grants-2002_02
Patent number
US06348468B1

Reaction notes

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