Chloride → HCID 18369404, compound

HRID 1699776Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)=[N:13][N:12]([CH2:23][CH2:24]O)[C:11](=[O:26])[CH:10]=2)=[CH:5][CH:4]=1.[Cl-].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=3)=[N:13][N:12]([CH2:23][CH2:24][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:11](=[O:26])[CH:10]=2)=[CH:5][CH:4]=1

Participants

Reactant 3

HCID 312Chloride

HCID 8083Morpholine

HCID 9906490HCID 9906490, compound

Product 1

HCID 18369404HCID 18369404, compoundYield 42.6%

Procedure

After 5,6-bis(4-methoxyphenyl)-2-(2-hydroxyethyl)-2H-pyridazin-3-one was reacted with paratoluenesulfonyl chloride in a similar manner as in Example 116-(2), a further reaction was conducted with morpholine, whereby the title compound was obtained in a yield of 42.6%.

Workup

customa further reaction

Sources & evidence

ORD record: ord-386787ff98fc4fb998e2501e72b51b95
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06348468B1

Reaction notes

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