(Chloromethyl)cyclopropane → HCID 18369334, compound

HRID 1699786Notes

Reaction equation

HRID 1699786 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[C:15]([C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=3)=[N:14][NH:13][C:12](=[O:24])[CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].Cl[CH2:26][CH:27]1[CH2:29][CH2:28]1>>[CH:27]1([CH2:26][N:13]2[C:12](=[O:24])[CH:11]=[C:10]([C:4]3[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=3)[C:15]([C:16]3[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=3)=[N:14]2)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 80013(Chloromethyl)cyclopropaneHCID 18369307HCID 18369307, compound

Product 1

HCID 18369334HCID 18369334, compoundYield 93.8%

Procedure

Using 5-(3-fluoro-4-methoxyphenyl)-6-(4-methoxyphenyl)-2H-pyridazin-3-one and (chloromethyl)cyclopropane as starting materials, the procedures of Example 146 were repeated likewise, whereby the title compound was obtained in a yield of 93.8%.

Sources & evidence

ORD record
ord-9850035327ac4c75a4f9c8ec11f545b3
Source dataset
uspto-grants-2002_02
Patent number
US06348468B1

Reaction notes

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