HCID 22388123, compound → 3H-Imidazo[4,5-b]pyridine-5-carbonitrile, 2-methyl-

HRID 1699817Notes

Reaction equation

HRID 1699817 reaction equation
BrC1C2C(=CC=CC=2)C=CC=1C[N:13]1[C:17]2=[N:18][C:19]([C:22]#[N:23])=[CH:20][CH:21]=[C:16]2[N:15]=[C:14]1[CH3:24].BrC1C2C(=CC=CC=2)C=CC=1CN1C2C(=NC(C#N)=CC=2)N=C1C>>[CH3:24][C:14]1[NH:15][C:16]2[C:17]([N:13]=1)=[N:18][C:19]([C:22]#[N:23])=[CH:20][CH:21]=2

Participants

3

Reactant 2

HCID 22388123HCID 22388123, compoundHCID 22388467HCID 22388467, compound

Product 1

HCID 223881363H-Imidazo[4,5-b]pyridine-5-carbonitrile, 2-methyl-Yield 343.2%

Procedure

In the same manner as in the following Preparation Example 14-2, 3-(1-bromonaphthalen-2-yl)methyl-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile (139 mg) and 1-(1-bromo-naphthalen-2-yl)methyl-2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile (96 mg) were respectively obtained as pale-brown crystals and pale-brown amorphous from 2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile (200 mg).

Sources & evidence

ORD record
ord-f9aa6ed391504cffaf1e00122be5f369
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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