Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | HCID 22388556 | HCID 22388556 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | HCID 22387815 | HCID 22387815 | 94.8% |
Reaction Steps
2-(2,4-Dichlorobenzoyl)-7-(ethoxycarbonyl)-3,5-dimethylbenzo[b]furan (0.78 g) and hydrazine monohydrate (0.70 g) were stirred in ethylene glycol (6.5 ml) at 140° C. for 2 hr. After cooling, potassium hydroroxide (0.75 g) was added and the mixture was stirred at 150° C. for 4 hr. After cooling, ice and concentrated hydrochloric acid were added and precipitate was collected by filtration. The precipitate was washed with water and diisopropyl ether and dried to give the objective compound (0.66 g) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06348474B1 |
|---|
| Source dataset | uspto-grants-2002_02 |
|---|
| ORD ID | ord-a48f36c6b44441f982e8094de00169a1 |
|---|
| Source note | uspto-grants-2002_02 |
|---|
