反应详情

Methyl 4-((2,2-dimethoxy)ethoxy)benzoate (10.00 g) and polyphosphoric acid (20.00 g) were refluxed in 1,2-dichloroethane (50 ml) for 1 hr. After cooling, ice was added, and the separated organic layer was washed with 10% hydrochloric acid. The mixture was dried over magnesium sulfate, concentrated and purified by column chromatography to give the objective compound (0.86 g).

1. temperatureAfter cooling
2. additionice was added
3. washthe separated organic layer was washed with 10% hydrochloric acid
4. dry with materialThe mixture was dried over magnesium sulfate
5. concentrationconcentrated
6. custompurified by column chromatography