Methyl iodide → HCID 22388120, compound

HRID 1699860Notes

Reaction equation

HRID 1699860 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH2:4][NH:5][N:6]1[C:10]2[CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[OH:20].[CH3:26]I>CN(C=O)C>[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH2:4][NH:5][N:6]1[C:10]2[CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=[CH:14][C:9]=2[N:8]([CH3:26])[C:7]1=[O:20]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178468677HCID 178468677, compound

Product 1

HCID 22388120HCID 22388120, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium hydrite (0.080 g, 60% suspension in oil) was added to a solution of 1-(2,4-dichlorobenzylamino)-2-hydroxy-6-(ethoxycarbonyl)benzimidazole (0.396 g) in N,N′-dimethylformamide (4 ml), and the mixture was stirred at room temperature for 1 hr. Methyl iodide (0.307 g) was added, and the mixture was stirred for 2 hr. The precipitated crystals were collected by filtration, washed with water and ethanol and dried to give the objective compound (0.348 g).

Workup

  1. stirringthe mixture was stirred for 2 hr
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water and ethanol
  4. customdried

Sources & evidence

ORD record
ord-beeb8647e4ee42469bd3aa3069cbb6f9
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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