Hydrochloric Acid → HCID 22387924, compound

HRID 1699863Notes

Reaction equation

HRID 1699863 reaction equation
[Cl:1][C:2]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:9]2[CH:10]=[C:11]([C:14]([O:16]CC)=[O:15])[CH:12]=[CH:13][C:8]=2[N:7]=[N:6]1.[OH-].[Na+].C(O)C.Cl>O>[C:14]([C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[N:6][N:5]([CH2:4][C:3]3[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:2]=3[Cl:1])[C:9]=2[CH:10]=1)([OH:16])=[O:15]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 22388450HCID 22388450, compound

Product 1

HCID 22387924HCID 22387924, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-(2,4-Dichlorobenzyl)-6-(ethoxycarbonyl)benzotriazole (0.60 g) was refluxed under heating in a mixed solvent of 5% aqueous solution of sodium hydroxide (6 g) and ethanol (20 g) for 0.5 hr. After cooling, concentrated hydrochloric acid (4 ml) and water (10 ml) were added to the reaction mixture, and the mixture was extracted with ethyl acetate, concentrated and dried to give the objective compound (0.50 g) as a crude product.

Workup

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. concentrationconcentrated
  4. customdried

Sources & evidence

ORD record
ord-5f46748125454e2a92013a550b989a1d
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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