Hydrochloric Acid → HCID 22387751, compound

HRID 1699878Notes

Reaction equation

HRID 1699878 reaction equation
Cl.C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)=[O:6])C.[OH-].[Na+].Cl>C(O)C>[ClH:25].[C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)([OH:6])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388209HCID 22388209, compound

Product 1

HCID 22387751HCID 22387751, compoundYield 129.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

6-(Ethoxycarbonyl)-3-(2,4-dichlorobenzyl)-3,4-dihydro-2-methylquinazoline hydrochloride (0.68 g) in a mixture of a 10% aqueous sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 60° C. for 1 hr. After standing cool the reaction mixture, concentrated hydrochloric acid (5 ml) was added and the precipitate was collected by filtration. The precipitated was washed with toluene and 2-propanol and dried to give the objective compound (0.41 g) as white crystals.

Workup

  1. additionwas added
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitated was washed with toluene and 2-propanol
  4. customdried

Sources & evidence

ORD record
ord-2ad808a9365641889d4ce5514cbede07
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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