Methyl pyruvate → HCID 22388504, compound

HRID 1699888Notes

Reaction equation

HRID 1699888 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][C:3]=1[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[Cl:22].[C:23](OC)(=[O:27])[C:24]([CH3:26])=O>C1(C)C=CC=CC=1>[Cl:22][C:16]1[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=1[CH2:14][N:13]1[C:3]2[C:2](=[CH:12][CH:11]=[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:4]=2)[N:1]=[C:24]([CH3:26])[C:23]1=[O:27]

Participants

4

Reactant 2

HCID 11748Methyl pyruvateHCID 22387919HCID 22387919, compound

Product 1

HCID 22388504HCID 22388504, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of ethyl 4-amino-3-(2,4-dichlorobenzylamino)benzoate (1.90 g) and methyl pyruvate (0.55 ml) in toluene (15 ml) was heated under reflux for 1 hr. The reaction mixture was concentrated. The residue was washed with methanol and dried to give the object compound (0.50 g) as yellow crystals.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hr
  3. concentrationThe reaction mixture was concentrated
  4. washThe residue was washed with methanol
  5. customdried

Sources & evidence

ORD record
ord-708b1739226743b98f0b292a186e2516
Source dataset
uspto-grants-2002_02
Patent number
US06348474B1

Reaction notes

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