反应详情

To a solution of 3-chloro-4-methylbenzyl alcohol (2.00 g) and triethylamine (8.9 ml) in a dimethyl sulfoxide (10 ml) was added sulfur trioxide-pyridine complex (4.47 g) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was poured into ice water, and extracted with ether. The organic layer was washed with 1N hydrochloric acid, saturated brine and a saturated aqueous sodium hydrogencarbonate solution, dried over magnesium sulfate, and concentrated to dryness under reduced pressure to give the objective compound (1.40 g) as a pale-yellow oil.

1. temperaturecooling
2. extractionextracted with ether
3. washThe organic layer was washed with 1N hydrochloric acid, saturated brine
4. dry with materiala saturated aqueous sodium hydrogencarbonate solution, dried over magnesium sulfate
5. concentrationconcentrated to dryness under reduced pressure