2-Pentanol → HCID 54554403, compound

HRID 1699978Notes

Reaction equation

HRID 1699978 reaction equation
[C:1]1([S:7]([NH:10][CH:11]([CH3:16])[CH2:12][C:13]([OH:15])=[O:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][CH:18](O)[CH2:19][CH2:20][CH3:21]>OS(O)(=O)=O.C1(C)C=CC=CC=1>[CH3:17][CH:18]([O:14][C:13](=[O:15])[CH2:12][CH:11]([NH:10][S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:9])=[O:8])[CH3:16])[CH2:19][CH2:20][CH3:21]

Participants

5

Reactant 2

HCID 223862-PentanolHCID 18370034HCID 18370034, compound

Product 1

HCID 54554403HCID 54554403, compoundYield 77.6%

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 1140TolueneSolvent

Procedure

The mixture of 2.0 gr DL-N benzensulfonyl-3 aminobutyric acid (I), 1.2 gr 2-Pentanol, 30 ml toluene and 0.04 gr H2SO4 (conc) was heated under reflux for ca 6 hr. The reaction was treated as in the previous example. 2.0 gr of the ester was obtained, confirmed by spectroscopy.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for ca 6 hr

Sources & evidence

ORD record
ord-b81470bc53cc43c08aa976ca691fc90f
Source dataset
uspto-grants-2002_02
Patent number
US06348614B1

Reaction notes

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